DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE
(4-CHLOROPHENYL)(DIMETHOXYPHOSPHINYL)METHYL PHOSPHORIC ACID DIMETHYL ESTER
CAS: 76541-72-5
Molecular Formula: C11H17ClO7P2
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE - Names and Identifiers
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE - Physico-chemical Properties
| Molecular Formula | C11H17ClO7P2 |
| Molar Mass | 358.65 |
| Solubility | DMSO: 5mg/mL |
| Appearance | crystalline |
| Color | white |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days. Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX). |
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | TB8817000 |
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE - References
| biological activity | Mifobate (SR-202) is a potent and specific antagonist of PPAR gamma, selective inhibition of thiazolidinedione (TZD)-induced PPARγ transcriptional activity (IC50=140 μm). Mifobate does not affect basal or ligand-stimulated transcriptional activity of PPAR alpha, PPAR beta or FXR. Mifobate has anti-obesity and anti-diabetic effects. |
| Animal Model: | Eight-week-old male ob/ob mice |
| Dosage: | 400 mg/kg |
| Administration: | Feed (food admixture maintained for 20 days) |
| Result: | Prevented the time-dependent increase in glucose concentrations. |
Last Update：2024-04-09 19:05:18
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View History
DIMETHYL (ALPHA-DIMETHOXYPHOSPHINYL-P-CHLOROBENZYL) PHOSPHATE
4-环戊基-1H-吡唑
(1-异戊基-1H-吡唑-4-基)硼酸
7-羟基-4-苯基-2H-苯并吡喃-2-酮
2-氨基-5-氟二苯甲酮
2-氨基-3-溴-5-硝基苄腈
(2S)-2-[叔丁氧羰基]氨基-3-甲基-3-丁烯酸
4-环戊基-1H-吡唑
(1-异戊基-1H-吡唑-4-基)硼酸
7-羟基-4-苯基-2H-苯并吡喃-2-酮
2-氨基-5-氟二苯甲酮
2-氨基-3-溴-5-硝基苄腈
(2S)-2-[叔丁氧羰基]氨基-3-甲基-3-丁烯酸